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Nevertheless, his case is sometimes cited as an example of vitamin B12 deficiency and how severe it can get with time, if left untreated, it can lead to serious health issues, including neurological symptoms like dementia

Daratumumab is approved as monotherapy and in combination with IMiD drugs (i.e., lenalidomide or pomalidomide based on the POLLUX, EQUULEUS, and APOLLO trials) or PIs (i.e., bortezomib or carfilzomib based on the CASTOR and CANDOR trials), plus dexamethasone for RRMM patients

When vitamin B12 levels are too low, the production of red blood cells is altered, causing megaloblastic anemia

However, once reconstituted with bacteriostatic water , the clock starts immediately