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Similarly, the blood-CSF barrier is formed by the choroid plexus epithelium, controlling the exchange between the blood and the CSF, although allowing more molecules to cross compared to the BBB (Pardridge, 2011)

The accumulation of A in astrocytes is responsible for increased ROS production and decreased glutathione levels, leading to oxidative stress and neuronal vulnerability (Allaman et al., 2010)

Drawbacks of inserting protein tags Although the use of protein tags has revolutionized protein science, certain drawbacks need to be considered before tags are added: 1

The non-enzymatic succinylation is mainly mediated by intracellular succinyl-CoA which can be modulated by succinyl-CoA metabolism-targeting enzymes, such as OXCT1, a member of the CoA transferase family I [49], and SUCLA2/SUCLG2, the ADP-forming succinyl-CoA synthetase [32, 50]