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One of these derivatives, deferiprone (3-hydroxy-1,2-dimethylpyridin-4(1 H )-one

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Furthermore, AP attenuated NF-B activation and inhibited the expression of IL-1 and TNF- but did not reverse the level of TLR4, an effect that might be attributed to the suppressive effects of Nrf2 and HO-1 on NF-B (Shen et al., 2024a)

Within the latter family, two primary receptors are of paramount importance: RIG-I, which recognizes 5-triphosphorylated or diphosphorylated single-stranded RNA (ssRNA) and acts as the main cytosolic RNA sensor [215, 216], and MDA5, which recognizes viral RNA replicating in the cytoplasm [217, 218]