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To investigate whether one or both putative binding sites were functional, we cloned fragments of 98 and 96 bp of the human IGF-1 3 UTR mRNA (NM_ 000618) containing the two putative miRNA-binding sites into the psiCHEK-2 vector (Supplementary Fig

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10.1021/acschemneuro.6b00146 32 DiwakarlaS.NylanderE.GrnbladhA.VangaS

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