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However, Phase 3 trials encountered setbacks due to incorrect dosages and regimens

It has been observed that repeated doses of DCA resulted in loss of GSTZ1-1 protein and activity, probably due to post-translationally modifications of the enzyme 85

indeed, Th1 cells have pro-inflammatory effects (a CD4 + T cell subsets) as do CD8 + T cells, while Th2 cells and regulatory T cells (Tregs) have anti-inflammatory effects (152)