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A prudent Fragment 176-191 cycle length would be 4 weeks followed by a washout period of at least one week

Ann Pharmacother 2017;51:1099111

The systemic exposure of 7-HMG when calculated as percentage ratio of area under the curve of 7-HMG to mitragynine following mitragynine oral dosing of female beagle dogs 16 was found to be 12.6 1.6%