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Natriuretic Peptides Atrial Natriuretic Peptide (ANP) and B-type natriuretic peptide (BNP), the main natriuresis hormones, are synthesized in cardiac tissue in response to stretching that occurs with increases in blood volume and function to decrease extracellular fluid volume and increase renal sodium excretion (108)

Symptoms like persistent tiredness, irritability, or nausea might indicate a deficiency, which is common in individuals with low dairy or meat intake

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But given the wide range of symptoms and the gradual rate at which they can appear, the condition is often overlooked or confused with something else