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In diabetic patients and animal models, phosphorylation of the Drp1-Ser637 site in podocytes and endothelial cells in a high-glucose environment drives the translocation of Drp1 to mitochondria, which in turn promotes mitochondrial fission (Wang W

Brain 138:25712583 Cramer SP, Simonsen H, Frederiksen JL, Rostrup E, Larsson HB (2014) Abnormal blood-brain barrier permeability in normal appearing white matter in multiple sclerosis investigated by MRI

The testes (or testicles) are the male gonads, the site of sperm production and maturation

After preliminary functional screening (see below), N-hexanoic-Tyr-Ile-(6)amino-hexanoic amide was chosen for further investigation with the expectation that it would be biologically active, metabolically stable, and BBB permeable