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In summary, these potentially novel Mmut p.L690Ins/p.L690Ins mice recapitulate many of the biochemical and clinical presentations of MMA seen in human patients, survive into adulthood, and can be rescued with gene therapy

Researchers have used assay for transposase-accessible chromatin with sequencing technology to compare chromatin accessibility between memory T cells and naive T cells, identifying 67,189 chromatin accessible regions in the same cohort of ME/CFS patients and healthy controls (the same population enrolled for T cell epigenetic and functional analyses)

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