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Thresholds based on cluster size, estimated R 2 , and the number of nested CGs were applied to highlight regions most consistently supported across independent studies, following general M-QTL practices 86,87

35,36 Amino Acids and Cortisol, Norepinephrine L-lysine and L-arginine: L-lysine and L-arginine given orally were shown effective at reducing chronic anxiety in a double-blind placebo-controlled study published in 2007 by Smriga et al in the Journal of Biomedical Research

However, shifts in dietary patterns may also play a decisive role by altering the ecological conditions required for their persistence

High-level TGF signalling is characteristic of many stroma-rich tumour types, including CMS4 CRC [3] and is a major metastasis-promoting signalling pathway in late-stage CRC [45]