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To determine whether dysregulated hepatic glutathione homeostasis and TNF can synergistically contribute to hepatocyte death, we performed cell culture studies using both human hepatoma cells and mouse non-transformed hepatocytes

serine hydroxymethyltransferase (SHMT) transfers a one-carbon unit to THF, forming 5,10-methylene-THF

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In nonalcoholic fatty liver disease, the progression of which is closely associated with metabolic dysregulationsuch as insulin resistance and lipid accumulation (Zhao et al., 2017)MenSCs have been shown to modulate the expression of the key gene Rnf186 by secreting HGF