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Another tumor suppressor, retinoblastoma (Rb), can directly regulate the glutamine transporter ASCT2 ( SLC1A5 ) to reduce glutamine uptake via the transcription factor E2F3 (Reynolds et al., 2014)

Significant progress has been made in constructing GSH-responsive drug delivery systems (DDSs) capable of site-specific therapeutic release within the tumor microenvironment [15]