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Introduction Over the last two decades, protein-based therapeutics targeting tumor necrosis factor alpha (TNF) have become a foundational therapy for the treatment of inflammatory disorders

TNF- signaling results are varied, playing a role in both therapeutic effects in immunomodulation, infectious pathogen resistance, and tumour resistance, as well as pathogenic effects by causing autoimmune diseases such as rheumatoid arthritis (RA) and worsening infections through excessive inflammation [54]

CooperLBBensonLMentzRJSavareseGDeVoreADCarreroJJet alAssociation between potassium level and outcomes in heart failure with reduced ejection fraction: a cohort study from the Swedish heart failure registry

Levels decline with age, which is why thinning accelerates after thirty