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In addition to MDR1 and MRP1, other mechanisms may mediate tumor cell resistance to cisplatin

Understanding Dark Spots Dark spots, medically known as hyperpigmentation, occur when certain areas of the skin produce more melanin than usual

Three distinctive cellular protective mechanisms against ferroptosis Studies have hitherto demonstrated that cells may have evolved at least three defense systems with different subcellular localizations, of which cytosol- and mitochondria-localized GPx4 confers the major protection against lipid peroxidation, while ferroptosis suppressor protein 1 (FSP1) acts mainly on the plasma membrane, and dihydroorotate dehydrogenase (DHODH) is a major defensive arm in mitochondria

Single-cell sequencing allows for finer analyses, but its implementation for routine patient care is nowadays unrealistic