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Neuroprotective effects of HTR1A antagonist WAY-100635 on scopolamine-induced delirium in rats and underlying molecular mechanisms

Hyperglycemia, AGEs, mitochondrial oxidative stress and ultrafiltration cytokines act on renal tubular cells and trigger multiple cellular pathways such as PKC-, -, and -, NF-B, P38 and ERK1/2 pathways, further exacerbating renal tubular cell hypertrophy, apoptosis, and accumulation of tubulointerstitial inflammatory factors (51)

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A 12-h day/night cycle allows the animals to maintain a normal circadian rhythm, with free access to food and water