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A: Some studies suggest activity when administered orally or via injection in animal models, but this is still under investigation and not clinically validated

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In contrast, when tissue folate or cobalamin stores are intact (Silberberg et al, 1997) or in the case of an alteration of the transsulfuration pathway dependent on vitamin B 6 deficiency or on heterozygosity for a CBS defect (Bostom et al, 1995a), an excessive methionine supply might lead to an important elevation of plasma homocysteine

Strategically, this approach reframes osteoarthritis as a dynamic, potentially modifiable process, especially in early or post-traumatic stages