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Managing missed doses appropriately is important for maintaining therapeutic benefits while avoiding adverse effects from irregular dosing patterns

The recommended dosage of Pemetrexed Injection for maintenance treatment of non-squamous NSCLC in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m2 as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle until disease progression or unacceptable toxicity after four cycles of platinum based first-line chemotherapy

doi: 10.1093/rheumatology/40.7.806 503 LoebelMGrabowskiPHeideckeHBauerSHanitschLGWittkeKet al

Hepatoprotective effect of lawsone on rifampicin-isoniazid induced hepatotoxicity in in vitro and in vivo models