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Mechanistically, mTORC1 promotes the proteasome-mediated destabilization of CREB2 to suppress SIRT4 (a mitochondria-localized member of the sirtuin family), which inhibits GDH, thereby enhancing GDH enzymatic activity

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Chronic exposure to ethanol can lead to decreased serotonin levels due to its effects on the synthesis and release of serotonin, primarily by influencing tryptophan metabolism