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It is challenging to define cellular senescence in erythrocytes, since these cells are terminally differentiated and their aging is not accompanied by the senescence-associated secretory phenotype (SASP) like in the case of nucleated cells [495]

The activated NLRP3 inflammasome will cause rapid activation of pro-inflammatory factors in the intestinal tract, and continuously cause cellular autophagy, which step by step exacerbates the inflammatory response, leading to more and more severe intestinal injury

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& Cardenas, J