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Hence, some drug development focuses on peripherally restricted KOR agonists to retain analgesic efficacy with a more favorable adverse effect [61]

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Similarly, curcumin up-regulated the expression of miRNA-15a and miRNA-16 while suppressing anti-apoptotic protein (Bcl-2) in breast cancer cells (Yang et al., 2010)

As alternative sampling technique, hair analysis, which is routinely applied in forensic and clinical toxicology (Kintz 2018), was recently applied in a large-scale pilot study to depict chronic exposure to mycotoxins confirming the accumulation of aflatoxins, T-2 toxin, and enniatins in hair matrix (Narvez et al