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Although olaparib and paclitaxel are still being tested in phase 1 clinical trials, a Hsp90 inhibitor called genetecibo (Ganetespib) has been shown to decrease tumour volume in xenografts produced from MDA-MB 231 ( in vitro and/or in vivo ( NP-based formulations called Liposomes-Doxorubicin nanodrug and Myocet, which were licenced for the treatment of breast cancer in 1998 (Taiwan) and 2000 (EMA), respectively, are now being used in clinical settings to treat metastatic breast cancer ( Numerous immunotherapies, including as immune checkpoint inhibitors, activation of cytotoxic T lymphocytes (CTLs), adaptive cell transfer-based treatment (ACT), and modification of the tumour microenvironment (TME), have been tried