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Treatment for TAILS generally includes topical steroids, antimalarials, and possibly switching to another TNF alpha inhibitor

A study involving a mouse model of western diet-induced obesity has demonstrated that 16 weeks of daily volitional exercise (running wheel) markedly prevents oxidative stress, myocardial fibrosis, and diastolic dysfunction with improved mitochondrial architecture through maintaining the levels of the myocardial heme oxygenase-1 (HO-1) [86]

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While caution is warranted when manipulating global -syn levels, we conclude that targeting toxic -syn seems a compelling strategy for therapeutic targets in PD