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demonstrated that ZDHHC5-mediated palmitoylation of beclin 1 serves as a core mechanism for maintaining neuronal autophagy, and its deficiency in AD murine models impairs autophagic function, exacerbating proteotoxic deposition, thereby leading to neurodegeneration, long-term potentiation (LTP) deficits, and memory deficits (167)

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Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME and Dixit VM (1996) FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex