amantadine and l-carnitine treatment of chronic fatigue syndrome PDF) Nutritional strategies for treating Carnitine | HealthyPlace

doi: 10.1007/s12640-020-00288-9

One-carbon metabolism has three pathways: the folate cycle, the methionine cycle and transsulfuration

Oxidative stress does not occur randomly it is driven upward by: undermethylation copper overload immune activation high sugar diets nutrient deficiencies sleep disruption physical or emotional stress environmental exposures When antioxidants are low, the brain cannot: regulate sensory input maintain mitochondrial energy detoxify inflammatory byproducts stabilize mood or attention manage stress hormones This creates a vulnerability window a period in which developmental timing can be disrupted by ordinary childhood stressors

Ribas et al., 2014