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Polyphenols exert their effects by targeting multiple pathways implicated in PD, including neuroinflammation, oxidative stress (reactive oxygen species, ROS), and protein aggregation, thereby potentially protecting vulnerable neurons (12) (Figure 1)

Invest Ophthalmol Vis Sci 58(8):20292029 Maldonado E, Morales-Pison S, Urbina F, Solari A (2023) Aging Hallmarks and the Role of Oxidative Stress

Diet and Lifestyle: In conjunction with injections, dietary adjustments or oral supplementation may be considered to maintain adequate vitamin B12 levels, especially in dietary-related deficiencies

Kidney tissue slices of Fh1 fl/fl Cre-negative control mice and Cre-positive mice in which Fh1 was lost (indicated hereafter as Fh1 / ) were subjected to the same protein extraction and cysteine labelling strategies as cells, and peptide oxidation ratios were normalised for protein abundance