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Therefore, consistent with ( the burden estimates for this measure under OMB control number 0938-1270, for all participating ASCs with regard to patient screening, we estimate removal of this measure will decrease burden for voluntary reporting for the CY 2025 reporting period by approximately 182,262 hours for 5,467,838 patients (0.033 hours 4,765 patients 50 percent response rate 4,590 ASCs 50 percent of ASCs) at a savings of $4,671,375 (182,262 hours $25.63/hour)

These results are in line with previous findings indicating that inhibition of mitochondrial complex I synergizes with mitochondrial antioxidants in impairing cancer cell fitness, supporting the notion that complex I is a dominant determinant of viability (28)

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