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Here, microbiome-derived short-chain fatty acids (SCFAs) and anti-inflammatory metabolites can suppress NLRP3 activity by inhibiting ROS production and modulating histone acetylation, promoting tissue homeostasis [31]

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Researchers at the University of Texas first characterized 5-amino-1MQ (5-amino-1-methyl quinolinium) in 2017 while searching for ways to inhibit nicotinamide-N-methyltransferase (NNMT) [1]