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This is consistent with the fact that exogenous metabolites often upregulate transcription factors and two-component systems that stimulate porin biosynthesis and mobilization

doi: 10.1016/j.clinre.2023.102221

Loren Pickart, who noticed that factors in younger human plasma could push older tissue toward a more youthful repair response

We revealed the molecular mechanism involved in the leptin-induced transcriptional regulation of carnitine palmitoyl transferase 1b ( Cpt1b ) and long-chain acyl-coenzyme A synthetase 1 ( Acsl1 ) using transfection/reporter assays and chromatin immunoprecipitation