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Conversely, mitochondria-derived ROS and pro-apoptotic proteins like Bax, Bid or Bim can trigger LMP, while caspase-8 regulates release of cathepsins [85]

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However, intervention with NAC is effective only when administered within 24 hours of APAP overdose, with early intervention leading to better prognosis

Moreover, NHANES data indicate that less than 9% of pregnant women meet the AI for choline (106)