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determined the cryo-EM structure of GIRK2 with PIP 2 and cholesteryl hemisuccinate (CHS), an analog of cholesterol (Figure 3)

ES also promoted ROS production, resulting in the enhancement of oxidative stress and the subsequent reduction in the expression of copper- transporting ATP7A, induction of ferroptosis, and SLC7A11 degradation in colorectal cancer cells [105]