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Metformin, commonly prescribed for diabetes, and proton pump inhibitors used for acid reflux can both reduce B12 absorption over time

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Clinical Benefits: Supports cellular energy production via the Krebs cycle and mitochondrial function Assists in the metabolism of carbohydrates, fats, and proteins Supports peripheral and central nervous system function Provides antioxidant protection against oxidative stress Supports immune function and recovery from illness May help address fatigue, low mood, and cognitive difficulties This combination is often recommended as part of a broader treatment plan for patients with chronic fatigue, nutritional deficiencies, or those who are not responding adequately to oral supplementation alone

Furthermore, succinyl CoA is necessary for the production of hemoglobin, the substance that carries oxygen in red blood cells