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In particular, pairing of the trigger RNA to an AGO2miRNA complex induces (1) a structural remodelling of the AGO2 protein that arranges the MID, N and PAZ domains for simultaneous engagement by two interlocked ZSWIM8 protomers

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The antibacterial effects of AC are attributed to several mechanisms: Cell membrane disruption : AC disrupts bacterial cell membranes by altering their permeability, leading to the leakage of essential intracellular components such as ions, proteins, and nucleotides

Lynch syndrome is an autosomal dominant inherited disorder associated with a high lifetime risk of developing CRC