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The comprehensive therapeutic architecture of Danshen thus orchestrates intervention across four pivotal stages of the gut-kidney axis continuum: executing bidirectional microbiome regulation through simultaneous suppression of pathogenic bacteria and promotion of beneficial microbial consortia, correcting metabolic pathway dysfunction via rectification of aberrant amino acid metabolic networks, modulating inflammatory signaling cascades through targeted inhibition of TGF-/Smad pathways, and providing direct renal cellular protection by attenuating fibrogenesis progression while restoring systemic metabolic homeostasis

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Journal of Biomolecular Nmr, 22 (2), 193-194

This dualistic outcome likely stems from the distinct physiological roles of lactate and associated acidosis: elevated lactate itself may not impair muscle function and might even support performance, yet the concomitant severe intracellular acidosis (pH 6.56.2), especially in fast-twitch fibers, reduces calcium sensitivity and impairs myosin ATPase activity, ultimately inducing muscle fatigue