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doi: 10.1016/j.metabol.2017.02.012 13 LaiQXiangWLiQZhangHLiYZhuGet al

6 CAR T-cell therapy toxicities: CRS, neurotoxicity, and management strategies While CAR T-cell therapy shows great therapeutic promise, it is also associated with serious toxicities, particularly CRS and immune effector cell-associated neurotoxicity syndrome (ICANS), which have become major safety challenges in clinical applications