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Immune recognition has not been completely eliminated by attempts to lessen this such as encasing nanoparticles with polyethylene glycol which may occasionally exacerbate inflammatory reactions [301]

C57BJ/6 male mice with 8-week old were divided into three groups (each containing 5 mice), and subjected to the TBH treatment by intraperitoneally injecting TBH at dose of 300 mg/kg