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Shear-induced endothelial nos activation and remodeling via heparan sulfate, glypican-1, and syndecan-1

The collagen fiber type transitions gradually from the outer to the inner layersthe outer layer is primarily composed of tension-resistant type I collagen, while moving inward, it gradually mixes with type II collagen extending to the edge of the nucleus pulposus, forming a tough ring structure that provides mechanical support to the disc by restricting NP displacement and resisting compressive loads

Therefore, the generalization of our findings necessitates further studies with precise diagnoses and larger study cohorts

In: Casida JE, editor