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In addition , new variants are appearing to be clinically more virulent though indirect evidence is consistant with vaccines still being efficacious ( 99% of current fatalities are among the unvaccinated and the vast majority of hospitalizations is among the unvaccinated population)

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It emphasizes the need for a pharmaceutical-grade, good manufacturing practice-compliant API infrastructure first

Regulatory Framework: Key FDA Guidance Documents for Nasal Sprays The foundation of nasal spray testing requirements in the United States is established by two primary FDA guidance documents, both from the Center for Drug Evaluation and Research (CDER): FDA CDER 2002 Nasal Spray and Inhalation Solution, Suspension and Spray Drug Products Chemistry, Manufacturing and Controls Documentation (CMC Guidance): Defines the CMC documentation requirements for new drug applications (NDAs) and abbreviated new drug applications (ANDAs) involving nasal spray and inhalation drug products