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Animal studies have suggested that biotin deficiency can be teratogenic (causing birth defects) in some species, raising concerns that even marginal biotin deficiency might be undesirable in pregnancy

Signs and symptoms of a B12 deficiency are arms and legs that feel weak and sore, poor reflexes, unpleasant body odor, menstrual difficulties, diminished sensory perception, clumsiness, stammering and jerking limbs

For patients with a very specific goal of fat metabolism support, it can be a useful tool, but it is not a replacement for tesamorelin when visceral fat reduction is the clinical objective