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In general, hydrophilic amino acids contribute to the formation of a hydrophobic pocket in the H-site adjacent to the GSH-binding site (Figure 3B&C) [80, 85]

Conduct phase I/II clinical trials with rigorous pharmacokinetic/pharmacodynamic (PK/PD) monitoring, using validated biomarkers to ensure target engagement (e.g., reduced urinary 4-HNE levels) and safety (e.g., no iron deficiency)

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Vitamin B12 deficiency may affect between 1.5 to 15 percent of people