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10.1038/nature08768 8 Biyik-SitR.KruerT.DoughertyS.BradleyJ

Adipogenic changes of hepatocytes in a highfat dietinduced fatty liver mice model and nonalcoholic fatty liver disease patients

An increased ratio of succinate to -KG in cancers resulting from impaired succinate dehydrogenase (SDH) activity is related to pervasive DNA hypermethylation, which contributes to the downregulation of key genes implicated in cell differentiation and cancer stages 102