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As long as the vial seal remains intact, refrigeration offers no additional benefit and may even introduce risk

In the CY 2024 PFS final rule, we also discussed a proposed timing cutoff such that changes to savings or losses for a benchmark year that were finalized after notification to the ACO of the initial determination of shared savings or shared losses for a given performance year would be reflected in the adjusted benchmark applied to any subsequent performance year during the relevant agreement period but would not be retroactively applied to completed performance years in the agreement period (88 FR 79198 through 79200)

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Our testers were divided on the taste with some preferring to add to a drink or food, rather than taking directly