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doi: 10.1080/19490976.2020.1848158 123 ZawadzkaK.KauziskaK.wierzM

Agomelatine protects against permanent cerebral ischaemia via the Nrf2-HO-1 pathway

A rapid reduction in Sb9 expression levels in DCs after in vivo injection may explain why DCs are resistant to CTL-mediated killing in vitro but not in vivo (86)

While researchers have explored its potential for neurological and metabolic conditions, the clearest clinical benefits are in liver health.4 6 7 Doses as low as 250mg/day have shown modest improvements in some liver studies, but 500mg/day is the minimum dose that consistently produces meaningful benefits.41 In patients with primary biliary cholangitis (PBC), 500mg/day lowered key liver enzymes linked to inflammation and damage.9 There is evidence that higher doses often perform better