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Although preclinical studies and limited clinical trials provide supportive evidence, larger and well-designed human clinical trials are still required to confirm long-term efficacy, dose-response relationships, and safety in metabolic disease conditions

[DOI] [PMC free article] [PubMed] [Google Scholar] 60.Armour M., Al-Dabbas M.A., Ee C., Smith C.A., Ussher J., Arentz S., Lawson K., Abbott J