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It is considered secondary if it occurs in association with another autoimmune disorder such as lupus, RA, or systemic sclerosis.[ref] One of the frequent blood tests used for Sjgrens checks for antibodies to the Ro or La proteins

doi: 10.1158/1078-0432.CCR-13-1105 52 FuscoC.MandrianiB.Di RienzoM.MicaleL.MalerbaN.CocciadiferroD.et al

2022) engineered Escherichia coli Nissle 1917 to stably express catalase and SOD, enabling active scavenging of intestinal reactive oxygen species, thereby more effectively repairing the epithelial barrier and modulating the microbiota

Disease severity seems to be strongly influenced by zygosity, mutation type, and environmental triggers