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In fact, TCA cycle flux in Th1 and Th17 cells, which controls the elevated succinate/ -ketoglutarate (-KG) ratio, promotes proinflammatory responses by stabilizing HIF-1 and increasing the expression of inflammatory cytokines such as IL-17 (141, 142)

J Affect Disord 143(13):3438 Stroup DF, Berlin JA, Morton SC et al (2000) Meta-analysis of Observational Studies in EpidemiologyA Proposal for Reporting

This review briefly introduces ferroptosis-related regulatory pathways and typical ferroptosis inducers and inhibitors, and describes the regulatory mechanism by which sorafenib inhibits HCC progression by inducing ferroptosis

doi: 10.1016/j.cmet.2020.07.013 77 CoriCFCoriGT