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Inhibition of miR-29b-3p or miR-378g upregulates NNMT expression and promotes osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), whereas overexpression of miR-29b-3p or miR-378g downregulates NNMT expression and inhibits osteogenic differentiation of BMSCs

18 Prevention Because of potential interactions from prolonged medication use, physicians should consider screening patients for vitamin B 12 deficiency if they have been taking proton pump inhibitors or H 2 blockers for more than 12 months, or metformin for more than four months