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3.2 CB-839 exposure leads to mitochondrial ROS accumulation in CLL cells Considering that glutathione is the main antioxidant that provides protection from excessive ROS production, we evaluated the consequences of glutathione synthesis inhibition on cellular ROS for 4 hours and mitochondrial SOX accumulation for 24 hours after incubation with CB-839 ( Figures 1E, G )

The presence of small air bubbles in GLP-1 injection pens is not dangerous and poses minimal risk to patients when the medication is administered subcutaneously (under the skin) as intended

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Enzyme activities and subcellular localization of members of the Arabidopsis glutathione transferase superfamily