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It is one of the ingredients in the Erlong Zuoci which is a traditional deafness prescription (calcined magnet, Rehmannia glutinosa Libosch., Cornus officinalis Sieb.et Zucc., Alisma orientale (Sam.) Juzep., Poria cocos (Schw.) Wolf, Paeonia suffruticosa Andr., Dioscorea opposita Thunb., Bupleurum chinense DC.), this prescription has been shown to elimination of DNA damage in hydrogen peroxide-induced auditory HCs, blocks up-regulation of cellular senescence proteins p21 and p-p53, increases p-ERK (ERK, extracellular regulated protein kinase) expression, reduces p-STAT3 (STAT3 activation is closely related to cancer) expression [171], and protects cochlear cells from ototoxicity caused by gentamicin [172]