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The combination of Man-MnO 2 @OVA27 with RT resulted in synergistic activation of the cGAS-STING pathway, promoting DC maturation, antigen cross-presentation, and activation of IFN- + and CD107 + CD8 + T cells

T cells that are bereft of operational leptin receptors display a hindered ability to morph into Th17 cells, an outcome stemming from subdued activation of STAT3 and its associated signaling trajectories (87)

The metabolic crosstalk between various cell types in the TME, combined with epigenetic regulation, creates a complex metabolic environment that promotes tumor growth, metastasis, and resistance to treatment[25, 26]