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What are the tissue-specific dosing protocols

The significant agreement with experimental affinities suggested one of several tentatively proposed binding modes

SOGALDI-PEF: Dapagliflozin Plus Spironolactone More Effective Than Monotherapy In patients with heart failure with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF), the combination of dapagliflozin plus spironolactone led to a greater reduction in NT-proBNP levels than dapagliflozin alone, indicating improved cardiac stress, according to results from the SOGALDI-PEF trial published in JACC